Endocrine Abstracts

This study evaluated the effects of the long treatment with cabergoline on seminal fluid parameters and sexual and gonadal function in hyperprolactinemic males. Eleven males with macroprolactinoma were treated with cabergoline at a dose of 1.5–2.5 mg a week for 6 months. All the patients suffered from libido impairment, reduced sexual potency, six had infertility. In three patients provocative bilateral galactorrhea was found.Seminal fluid analysis,...

Background: MiRNAs are small non-coding RNAs, which regulate biological and pathological processes, including organogenesis, apoptosis, cell proliferation and differentiation. Considering the complexity of the parathyroid cancer (PC) diagnosis, discovering of new markers of the disease, which may help to evaluate the prognosis before surgical treatment, becomes an important problem. We studied the differences in miRNA expression profile in the blood serum between patients with...

Objective: To assess the levels of osmolality, sodium in blood and urine, and copeptin level in patients after transnasal adenomectomy for pituitary adenomas.Materials and methods: A total of 154 patients, aged 18 to 65 years, were included in this study and underwent transnasal adenomectomy. Surgical treatment was performed in 73 patients with Cushing’s disease, 66 – acromegaly, 4 – prolactinoma, 9 – hormonally inact...

Growth hormone (GH) producing tumors are commonly associated with menstrual disorders and anovulation because of the direct effects of tumor mass on gonadotropins and possible association with hyperprolactinemia. However, some women with acromegaly get pregnant, which rises up a lot of questions about medication, complications and follow-up. We report outcomes of 7 cases of pregnancy in patients with active acromegaly. A median age of patients was 30 years, four of them were w...

Introduction: Epidemiological data for central diabetes insipidus (CDI) are quite sparse.Objectives: To provide an epidemiological data on CDI in different regions of Russia (20 from 83 Federal regions).Materials and methods: We used the Russian Registry for Central Diabetes Insipidus (RCDI) to study the epidemiological features of CDI.Results: A total of 2004 patients with CDI were recorded, 47% women and 59...

Case description: A 26-year-old female visited an endocrinologist for the first time in 2014 with complaint of neck swelling. Lab results revealed increased blood level of TSH, initially the diagnosis of hypothyroidism was set and levothyroxine therapy was initiated with consequent addition of thiamazole due to increasing levels of free T4 and TSH. In 2015 the diagnosis of TSH-secreting adenoma was made on the basis of MRI findings (pituitary microadenoma 3.1 mm in size) and l...

BackgroundEctopic ACTH syndrome (EAS) is a rare cause of endogenous hypercortisolism.ObjectiveTo analyze clinical, biochemical features and treatment outcomes of patients with EAS.Materials and methodsRetrospective, observational study on 129 patients (79 women, 50 men) with EAS diagnosed between 1990 and 2020. Plasma levels of ACTH (reference range: morning 7.2&#...

ObjectivesTo assess diagnostic and prognostic markers of permanent and transient postoperative diabetes insipidus.Patients and methodsThe study included 152 patients undergone endoscopic endonasal transsphenoidal surgery aged from 18 to 65 years with median 40 [31; 52] years. Seventy three patients had Cushing disease, 66 – acromegaly, 4 – prolactinoma, 9 – hormonally inactive adenoma, 1 –...

Introduction: The occurrence of autoimmune adverse events is a frequent complication of oncoimmunotherapy with antibody drugs to PD-1.Clinical Case: At the age of 33, the patient was diagnosed with melanoma, which was surgically removed. After 3 years, there was a progression with the appearance of liver metastases which were embolized with further initiation of oncoimmunotherapy with nivolumab. As a complication of this treatment the patient developed a...

Introduction: Corticotropinomas constitute up to 45% of aggressive pituitary tumors, which characterized by rapid and invasive growth, a high Ki-67 index, resistance to conventional treatments and recurrence in 15-20% of the cases. Progression of corticotroph tumor after bilateral adrenalectomy or Nelson’s syndrome is a frequent severe complication and may present with aggressive tumor behavior.Clinical case: A Cushing disease was diagnosed in a wom...